Variation in gastric alcohol dehydrogenase and the risk of alcohol dependence
نویسندگان
چکیده
منابع مشابه
Association of the gastric alcohol dehydrogenase gene ADH7 with variation in alcohol metabolism.
Seven alcohol-metabolizing enzymes are encoded by the human alcohol dehydrogenase (ADH) gene cluster on chromosome 4q22-23. One of these genes, ADH7, is uniquely expressed in the stomach mucosa and can influence metabolism of alcohol before its absorption into the blood. However, the contribution of ADH7 to the overall genetic variation in alcohol oxidation in vivo is unknown. Data on in vivo a...
متن کاملProtective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission Indians.
OBJECTIVE Two alcohol dehydrogenase genes (ADH2 and ADH3 on chromosome 4) and one aldehyde dehydrogenase gene (ALDH2 on chromosome 12) exhibit functional polymorphisms. The goal of this study was to determine whether any associations exist between the ADH2, ADH3, and ALDH2 polymorphisms and alcohol dependence in a group of Native Americans. An additional goal was to determine if any association...
متن کاملInfluence of Genetic Variation in Alcohol Dehydrogenase
RESULTS—Moderate to heavy alcohol consumption ( 5 g/day for women and 10 g/day for men) was associated with a decreased risk of diabetes among women (odds ratio [OR] 0.45 [95% CI 0.33–0.63]) but not men (1.08 [0.67–1.75]). ADH1C genotype modified the relation between alcohol consumption and diabetes for women (Pinteraction 0.02). The number of ADH1C*2 alleles, related to a slower rate of ethano...
متن کاملVariation in alcohol pharmacokinetics as a risk factor for alcohol dependence.
BACKGROUND The significant association between alcohol dehydrogenase (ADH)-2 genotype and alcohol-dependence risk, demonstrated in both Asian and non-Asian populations, suggests a link between the metabolism of alcohol (ethanol) and individual differences in susceptibility to dependence. METHODS We tested this hypothesis by following up on subjects who took part in the Alcohol Challenge Twin ...
متن کاملMeta-analysis of the effects of alcohol dehydrogenase genotype on alcohol dependence and alcoholic liver disease.
The purpose of this paper is to assemble and evaluate existing data on the effect of genetic variation in ADH2 and ADH3 on the risk of alcohol dependence, and on the risk of alcoholic liver disease. Calculations of odds ratios and their confidence limits, and tests for heterogeneity of the results from the available studies, have been performed. It is clear that possession of the ADH2-2 allele ...
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ژورنال
عنوان ژورنال: Archives of Forensic Medicine and Criminology
سال: 2016
ISSN: 0324-8267
DOI: 10.5114/amsik.2016.66401